Publications

Main Publications 

Wilkins RJ, Kannan A, Plass,SA, Wilson C, Kelly RDW, Tang CHM., Kotsantis P, Reijns MAM, Kanhere A, Petermann E (2024) Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress. bioRxiv 2024.2012.2016.628316. 10.1101/2024.12.16.628316.

Petermann E (2022) Conflicts with transcription make early replication late. Molecular Cell 82: 3315-3317

Petermann E, Lan L, Zou L (2022) Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids. Nature Reviews Molecular Cell Biology 8:521-540

Bowry A, Kelly RDW, Petermann E (2021) Hypertranscription and replication stress in cancer. Trends in Cancer 7: 863-877

Piberger AL, Bowry A, Kelly RDW, Walker AK, González-Acosta D, Bailey LJ, Doherty AJ, Méndez J, Morris JR, Bryant HE, Petermann E (2020) PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts. Nature Communications 11: 5863

Bowry A, Piberger AL, Rojas P, Saponaro M, Petermann E (2018) BET inhibition induces HEXIM1- and RAD51-dependent conflicts between transcription and replication. Cell Reports 25: 2061–2069

Kotsantis P, Marques Silva L, Irmscher S, Jones RM, Folkes L, Gromak N, Petermann E (2016) Increased global transcription activity as a mechanism of replication stress in cancer. Nature Communications 7: 13087 

Kotsantis P, Jones RM, Higgs MR, Petermann E (2015) Cancer therapy and replication stress: forks on the road to perdition. Adv Clin Chem 69: 91-138

Jones RM, Kotsantis P, Stewart GS, Groth P, Petermann E (2014) BRCA2 and RAD51 promote double-strand break formation and cell death in response to Gemcitabine. Mol Cancer Ther 13: 2412-2421

Jones RM, Mortusewicz O, Afzal I, Lorvellec M, Garcia P, Helleday T, Petermann E (2013) Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress. Oncogene 32: 3744-3753

Jones RM, Petermann E (2012) Replication fork dynamics and the DNA damage response. Biochem J 443: 13-26

Collaborations

Mackay, H.L., Stone, H.R., Ronson, G.E., Ellis, K., Lanz, A., Aghabi, Y., Walker, A.K., Starowicz, K., Garvin, A.J., Van Eijk, P., Koestler, S.A., Anthony, E.J., Piberger, A.L., Chauhan, A.S., Conway-Thomas, P., Vaitsiankova, A., Vijayendran, S., Beesley, J.F., Petermann, E., Brown, E.J., Densham, R.M., Reed, S.H., Dobbs, F., Saponaro, M. & Morris, J.R. (2024) USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication.  Nature Communications 15: 8102 .

Blakemore D, Vilaplana N, Almaghrabi R, Gonzalez E, Moya M, Ward C, Murphy GJ, Gambus A, Petermann E, Stewart GS, Garcia P (2021) MYBL2 and ATM suppress replication stress in pluripotent stem cells. EMBO Reports: e51120 

Landsverk HB, Sandquist LE, Bay LTE, Steurer B, Campsteijn C, Landsverk OJB, Marteijn JA, Petermann E, Trinkle-Mulcahy L, Syljuåsen RG (2020) WDR82/PNUTS-PP1 prevents transcription-replication conflicts by promoting RNA Polymerase II degradation on chromatin. Cell Reports 33: 108469

Nazeer R, Qashqari F, Albalawi A, Piberger AL, Tilotta MT, Read M, Hu S, Davis S, McCabe C, Petermann E, Turnell A (2019) Adenovirus E1B-55K targets SMARCAL1 for degradation during infection and modulates cellular DNA replication. J Virology doi:10.1128/JVI.00402-19

Ronson GE, Piberger AL, Higgs MR, Olsen AL, Stewart GS, McHugh PJ, Petermann E, Lakin ND (2018) PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation. Nature Communications 9: 746

Kotsantis P, Petermann E, & Boulton SJ (2018) Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place. Cancer Discovery 8: 537-555. 

Bayley R, Blakemore D, Cancian L, Dumon S, Volpe G, Ward C, Almaghrabi R, Gujar J, Reeve R, Raghavan M, Higgs M, Stewart GS, Petermann E, Garcia P (2018) MYBL2 supports DNA double strand break repair in haematopoietic stem cells. Cancer Research 78: 5767-5779. 

Benedict B, van Harn T, Dekker M, Hermsen S, Kucukosmanoglu A, Pieters W, Delzenne-Goette E, Dorsman JC, Petermann E, Foijer F, te Riele H (2018) Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells. eLife 7:e37868.

Kwok M, Davies N, Agathanggelou A, Smith E, Oldreive C, Petermann E, Stewart GS,Brown J, Lau A, Pratt G, Parry H, Taylor AMR, Moss P, Hillmen P, Stankovic T (2016) ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53 or ATM defective chronic lymphocytic leukemia cells. Blood 127: 582-595

Gagou ME, Ganesh A, Phear G, Robinson D, Petermann E, Cox A, Meuth M (2014) Human PIF1 helicase supports DNA replication and cell growth under oncogenic-stress. Oncotarget 5: 11381-11398

Da Costa D, Agathanggelou A, Perry T, Weston V, Petermann E, Zlatanou A, Oldreive C, Wei W, Stewart G, Longman J, Smith E, Kearns P, Knapp S, Stankovic T (2013) BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia. Blood Cancer J 3: e126

Zimmerman KM, Jones RM, Petermann E, Jeggo PA (2013) Diminished origin-licensing capacity specifically sensitizes tumor cells to replication stress. Mol Cancer Res 11: 370-380

Parplys AC, Petermann E, Petersen C, Dikomey E, Borgmann K (2012) DNA damage by X-rays and their impact on replication processes. Radiotherapy and Oncology 102: 466-471