Welcome to the

Petermann Lab

PhD studentship available

MRC DiMEN-DTP studentship avaliable as part of a collaboration project on a novel player in replication stress and based in our collaborator's lab in Liverpool, with visits to Birmingham.

About

We are interested in molecular mechanisms around DNA replication and genome stability. Replication stress is a central source of genomic instability in human diseases such as cancer, but also an important mechanism through which cancer therapies kill dividing cells.

We are particularly interested in obstacles to replication fork progression and how they arise. These include simple obstacles such as blocking lesions on the DNA template, and complex obstacles such as the transcription machinery and homologous recombination.

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Funding

The lab has been funded by Cancer Research UK, MRC, Worldwide Cancer Research, BBSRC, Wellcome Trust and the Royal Society.